A key question in developmental biology is how two sister cells with identical genomes follow different patterns of gene expression. Sporulation in Bacillus subtilis is a good model for how a single cell develops into two different cell types. Many mechanisms have been proposed to explain differential gene expression but without a quantitative analysis it has proven difficult to assess their validity. A combination of mathematical modeling and experiments enabled us to define the mechanism by which differential gene expression is achieved.
PUBLICATIONS:
REVIEWS:
PUBLICATIONS:
- Iber D, Clarkson J, Yudkin M, Campbell ID, The mechanism of cell differentiation in Bacillus subtilis, Nature (2006); 441, 371-374 Supplementary Material
- Iber D, A computational analysis of the impact of the transient genetic imbalance on compartmentalized gene expression during sporulation in Bacillus subtilis, J. Mol. Biol. (2006); 360, 15-20
- Iber D The spoIIA operon in Bacillus subtilis provides a quantitative example for individual fitness increase by co-regulation , Molecular Systems Biology (2006); 2, 43
- Iber D, Reduction of a detailed biological signaling model, Procedia Computer Science (2010); 1, 981-990
- Fengos G and Iber D, Prediction Stability in a data-based mechanistic model of sigmaF during sporulation in Bacillus subtilis. Sci Rep, accepted
REVIEWS:
- Iber D, The mechanistic basis of compartmentalized gene expression in Bacillus subtilis. Natural Computing (2005); 4:325-338